• Home   /  
  • Archive by category "1"

R Indacrinone Synthesis Essay

Citation data is made available by participants in Crossref's Cited-by Linking service. For a more comprehensive list of citations to this article, users are encouraged to perform a search inSciFinder.

  • The Evolution of Chemical High-Throughput Experimentation To Address Challenging Problems in Pharmaceutical Synthesis

    Shane W.KrskaDaniel A.DiRoccoSpencer D.DreherMichaelShevlin

    Accounts of Chemical Research201750 (12), 2976-2985

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Model for the Enantioselectivity of Asymmetric Intramolecular Alkylations by Bis-Quaternized Cinchona Alkaloid-Derived Catalysts

    Cyndi QixinHeAdamSimonYu-hongLamAndrew P. J.BrunskillNobuyoshiYasudaJiajingTanAlan M.HydeEdward C.ShererK. N.Houk

    The Journal of Organic Chemistry201782 (16), 8645-8650

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Asymmetric Synthesis of (−)-Pterocarine and (−)-Galeon via Chiral Phase Transfer-Catalyzed Atropselective Formation of Diarylether Cyclophane Skeleton


    Organic Letters201719 (7), 1804-1807

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Enantioselective Alkylative Kinetic Resolution of 2-Oxindole-Derived Enolates Promoted by Bifunctional Phase Transfer Catalysts

    EmilianoSorrentinoStephen J.Connon

    Organic Letters201618 (20), 5204-5207

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • A Series of Cinchona-Derived N-Oxide Phase-Transfer Catalysts: Application to the Photo-Organocatalytic Enantioselective α-Hydroxylation of β-Dicarbonyl Compounds


    The Journal of Organic Chemistry201681 (16), 7042-7050

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Pentanidium- and Bisguanidinium-Catalyzed Enantioselective Alkylations Using Silylamide as Brønsted Probase

    BoTengWenchaoChenShenDongChoon WeeKeeDhika AdityaGandamanaLiliZongChoon-HongTan

    Journal of the American Chemical Society2016138 (31), 9935-9940

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Asymmetric Protonation of Cumulenolates: Synthesis of Allenyl Aldehydes Facilitated by an Organomanganese Auxiliary

    AnimeshRoyBilal A.BhatSalvatore D.Lepore

    Organic Letters201618 (6), 1230-1233

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • The Discovery and Synthesis of the CGRP Receptor Antagonist MK-3207

    Ian M.BellPaul G.BulgerMarkMcLaughlin


    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Contemporary Asymmetric Phase Transfer Catalysis: Large-Scale Industrial Applications


    Organic Process Research & Development201519 (11), 1731-1746

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Cation-Controlled Enantioselective and Diastereoselective Synthesis of Indolines: An Autoinductive Phase-Transfer Initiated 5-endo-trig Process

    KrishnaSharmaJamie R.WolstenhulmePhillip P.PainterDavidYeoFranciscaGrande-CarmonaCraig P.JohnstonDean J.TantilloMartin D.Smith

    Journal of the American Chemical Society2015137 (41), 13414-13424

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Redox-Switchable Chiral Anions and Cations Based on Heteroatom-Fused Biferrocenes

    JiaweiChenDidier A.Murillo ParraRoger A.LalancetteFriederJäkle

    Organometallics201534 (17), 4323-4330

    Abstract | Full Text HTML | PDF | PDF w/ Links

  • Formation of 2-Cyano-2-siloxyvinylallenes via Cyanide-Induced Brook Rearrangement in γ-Bromo-α,β,γ,δ-unsaturated Acylsilanes


    The Journal of Organic Chemistry2015

  • 1. Corey EJ, Cheng X-M. The Logic of Chemical Synthesis. Wiley; New York: 1995. pp. 1–91.

    2. Jacobsen EN, Pfaltz A, Yamamoto H, editors. Comprehensive Asymmetric Catalysis, Vol. I–III. Springer-Verlag; Berlin: 2000.

    3. Jacobsen EN, Pfaltz A, Yamamoto H, editors. Comprehensive Asymmetric Catalysis, Supplement 1 & 2. Springer-Verlag; Berlin: 2004.

    4. Hoveyda AH. Asymmetric Catalysis in Target-Oriented Synthesis. In: Vögtle F, Stoddart JF, Shibasaki M, editors. Stimulating Concepts in Chemistry. Wiley-VCH; Weinheim: 2000. pp. 145–160.

    5. Trost BM. Asymmetric Catalysis: An Enabling Science. Proc. Natl. Acad. Sci. U.S.A. 2004;101:5348–5355.[PMC free article][PubMed]

    6. Taylor MS, Jacobsen EN. Asymmetric Catalysis in Complex Target Synthesis. Proc. Natl. Acad. Sci. U.S.A. 2004;101:5368–5373.[PMC free article][PubMed]

    7. Diels O, Alder K. Synthesen in der Hydroaromatischen Reihe. Justus Liebigs Ann. Chem. 1928;460:98–122.

    8. Stork G, van Tamalen EE, Friedman LJ, Burgstahler AW. Cantharidin. A Stereospecific Total Synthesis. J. Am. Chem. Soc. 1951;73:4501.

    9. Woodward RB, Bader FE, Bickel H, Frey AJ, Kierstead RW. The Total Synthesis of Reserpine. J. Am. Chem. Soc. 1956;78:2023–2025.

    10. Yates P, Eaton P. Acceleration of the Diels–Alder Reaction by Aluminum Chloride. J. Am. Chem. Soc. 1960;82:4436–4437.

    11. Hashimoto S.-i., Komeshima N, Koga K. Asymmetric Diels–Alder Reaction Catalysed by Chiral Alkoxyaluminium Dichloride. J. Chem. Soc., Chem. Commun. 1979:437–438.

    12. Hayashi Y. Catalytic Asymmetric Diels–Alder Reactions. In: Kobayashi S, Jørgensen KA, editors. Cycloaddition Reactions in Organic Synthesis. Wiley-VCH; Weinheim: 2002. pp. 5–55.

    13. Corey EJ. Catalytic Enantioselective Diels–Alder Reactions: Methods, Mechanistic Fundamentals, Pathways, and Applications. Angew. Chem., Int. Ed. 2002;41:1650–1667.[PubMed]

    14. Nicolaou KC, Snyder SA, Montagnon T, Vassilikogiannakis G. The Diels–Alder Reaction in Total Synthesis. Angew. Chem., Int. Ed. 2002;41:1668–1698.[PubMed]

    15. Corey EJ, Andersen NH, Carlson RM, Paust J, Vedejs E, Vlattas I, Winter REK. Total Synthesis of Prostaglandins. Synthesis of the Pure dl-E1, -F1α, -F1β, -A1, and -B1 Hormones. J. Am. Chem. Soc. 1968;90:3245–3247.[PubMed]

    16. Corey EJ, Bakshi RK, Shibata S, Chen C-P, Singh VK. A Stable and Easily Prepared Catalyst for the Enantioselective Reduction of Ketones. Applications to Multistep Syntheses. J. Am. Chem. Soc. 1987;109:7925–7926.

    17. Corey EJ, Helal CJ. Reduction of Carbonyl Compounds with Chiral Oxazaborolidine Catalysts: A New Paradigm for Enantioselective Catalysis and a Powerful New Synthetic Method. Angew. Chem., Int. Ed. 1998;37:1986–2012.

    18. Yoon TP, Jacobsen EN. Privileged Chiral Catalysts. Science. 2003;229:1691–1693.[PubMed]

    19. Nájera C, Sansano JM. Catalytic Asymmetric Synthesis of α-Amino Acids. Chem. Rev. 2007;107:4584–4671.[PubMed]

    20. Senanayake CH, Jacobsen EN. Chiral (Salen)Mn(III) Complexes in Asymmetric Epoxidations: Practical Synthesis of cis-Aminoindanol and Its Application to Enantiopure Drug Synthesis. In: Gadamasetti KG, editor. Process Chemistry in the Pharmaceutical Industry. Marcel Dekker; New York: 1999. pp. 347–368.

    21. Akutagawa S, Tani K. Asymmetric Isomerization of Allylamines. In: Ojima I, editor. Catalytic Asymmetric Synthesis. Wiley-VCH; New York: 2002. pp. 145–161.

    22. Nugent WA, RajanBabu TV, Burk MJ. Beyond Nature's Chiral Pool: Enantioselective Catalysis in Industry. Science. 1993;259:479–483.[PubMed]

    23. Farina V, Reeves JT, Senanayake CH, Song JJ. Asymmetric Synthesis of Active Pharmaceutical Ingredients. Chem. Rev. 2006;106:2734–2793.[PubMed]

    24. Blaser H-U, Schmidt E, editors. Asymmetric Catalysis on Industrial Scale: Challenges, Approaches and Solutions. Wiley-VCH; Weinheim: 2004.

    25. Eder U, Sauer G, Wiechert R. New Type of Asymmetric Cyclization to Optically Active Steroid CD Partial Structures. Angew. Chem., Int. Ed. Engl. 1971;10:496–497.

    26. Hajos ZG, Parrish DR. Stereocontrolled Total Synthesis of 19-Nor Steroids. J. Org. Chem. 1973;38:3244–3249.[PubMed]

    27. Hajos ZG, Parrish DR. Asymmetric Synthesis of Bicyclic Intermediates of Natural Product Chemistry. J. Org. Chem. 1974;39:1615–1621.

    28. Evans DA, Fitch DM, Smith TE, Cee VJ. Application of Complex Aldol Reactions to the Total Synthesis of Phorboxazole B. J. Am. Chem. Soc. 2000;122:10033–10046.

    29. Palomo C, Oiarbide M, Garcáa JM. The Aldol Addition Reaction: An Old Transformation at Constant Rebirth. Chem.-Eur. J. 2002;8:37–44.[PubMed]

    30. Ma J-A. Recent Developments in the Catalytic Asymmetric Synthesis of α- and β-Amino Acids. Angew. Chem., Int. Ed. 2003;42:4290–4299.[PubMed]

    31. Juaristi E, Soloshonok VA, editors. Enantioselective Synthesis of β-Amino Acids. Wiley & Sons; Hoboken: 2005.

    32. Vineyard BD, Knowles WS, Sabacky MJ, Bachman GL, Weinkauff DJ. Asymmetric Hydrogenation. Rhodium Chiral Bisphosphine Catalyst. J. Am. Chem. Soc. 1977;99:5946–5952.

    33. Lubell WD, Kitamura M, Noyori R. Enantioselective Synthesis of β-Amino Acids Based on BINAP–Ruthenium(II) Catalyzed Hydrogenation. Tetrahedron: Asymmetry. 1991;2:543–554.

    34. Drexler H-J, You J, Zhang S, Fischer C, Baumann W, Spannenberg A, Heller D. Chiral β-Amino Acid Derivatives via Asymmetric Hydrogenation. Org. Process Res. Dev. 2003;7:355–361.

    35. Drucker D, Easley C, Kirkpatrick P. Sitagliptin. Nat. Rev. Drug Discovery. 2007;6:109–110.[PubMed]

    36. Hsiao Y, Rivera NR, Rosner T, Krska SW, Njolito E, Wang F, Sun Y, Armstrong JD, III, Grabowski EJJ, Tillyer RD, Spindler F, Malan C. Highly Efficient Synthesis of β-Amino Acid Derivatives via Asymmetric Hydrogenation of Unprotected Enamines. J. Am. Chem. Soc. 2004;126:9918–9919. This paper describes the discovery of the rhodium-catalyzed enantioselective hydrogenation of β-enamino amide and ester substrates. [PubMed]

    37. Shultz CS, Krska SW. Unlocking the Potential of Asymmetric Hydrogenation at Merck. Acc. Chem Res. 2007;40:1320–1326.[PubMed]

    38. Xu F, Armstrong JD, III, Zhou GX, Simmons B, Hughes D, Ge Z, Grabowski EJJ. Mechanistic Evidence for an α-Oxoketene Pathway in the Formation of β-Ketoamides/Esters via Meldrum's Acid Adducts. J. Am. Chem. Soc. 2004;126:13002–13009.[PubMed]

    39. Clausen AM, Dziadul B, Cappuccio KL, Kaba M, Starbuck C, Hsiao Y, Dowling TM. Identification of Ammonium Chloride as an Effective Promoter of the Asymmetric Hydrogenation of β-Enamine Amide. Org. Process Res. Dev. 2006;10:723–726. This paper details the scale-up efforts of the enantioselective hydrogenation of a β-enamino amide toward the industrial scale synthesis of diabetes treatment Januvia®, as well as the impact of ammonium chloride as an additive to maintain efficiency and selectivity in this process.

    40. Noyori R, Kitamura M, Ohkuma T. Toward Efficient Asymmetric Hydrogenation: Architectural and Functional Engineering of Chiral Molecular Catalysts. Proc. Natl. Acad. Sci. U.S.A. 2004;101:5356–5362.[PMC free article][PubMed]

    41. Negishi E.-i., de Meijere A., editors. Handbook of Organopalladium Chemistry for Organic Synthesis. Vol. 1. Wiley & Sons; New York: 2002.

    42. de Meijere A, Diederich F, editors. Metal-Catalyzed Cross-Coupling Reactions. 1 & 2. Wiley-VCH; Weinheim: 2004.

    43. Luh T-Y, Leung M.-k., Wong K-T. Transition Metal-Catalyzed Activation of Aliphatic C–X Bonds in Carbon–Carbon Bond Formation. Chem. Rev. 2000;100:3187–3204.[PubMed]

    44. Frisch AC, Beller M. Catalysts for Cross-Coupling Reactions with Non-activated Alkyl Halides. Angew. Chem., Int. Ed. 2005;44:674–688.[PubMed]

    45. Netherton MR, Fu GC. Palladium-Catalyzed Cross-Coupling Reactions of Unactivated Alkyl Electrophiles with Organometallic Compounds. In: Tsuji J, editor. Topics in Organometallic Chemistry: Palladium in Organic Synthesis. Springer; New York: 2005. pp. 85–108.

    46. Kiso Y, Tamao K, Miyake N, Yamamoto K, Kumada M. Asymmetric Cross-Coupling Reactions of sec-Alkyl Grignard Reagents with Organic Halides in the Presence of a Chiral Phosphine-Nickel Complex as a Catalyst. Tetrahedron Lett. 1974;15:3–6.

    47. Hayashi T, Konishi M, Fukushima M, Mise T, Kagotani M, Tajika M, Kumada M. Asymmetric Synthesis Catalyzed by Chiral Ferrocenylphosphine-Transition Metal Complexes. 2. Nickel- and Palladium-Catalyzed Asymmetric Grignard Cross-Coupling. J. Am. Chem. Soc. 1982;104:180–186.

    48. Fischer C, Fu GC. Asymmetric Nickel-Catalyzed Negishi Cross-Couplings of Secondary α-Bromo Amides with Organozinc Reagents. J. Am. Chem. Soc. 2005;127:4594–4595.[PubMed]

    49. Arp FO, Fu GC. Catalytic Enantioselective Negishi Reactions of Racemic Secondary Benzylic Halides. J. Am. Chem. Soc. 2005;127:10482–10483.[PubMed]

    50. Zhou J, Fu GC. Cross-Couplings of Unactivated Secondary Alkyl Halides: Room-Temperature Nickel-Catalyzed Negishi Reactions of Alkyl Bromides and Iodides. J. Am. Chem. Soc. 2003;125:14726–14727.[PubMed]

    51. Son S, Fu GC. Nickel-Catalyzed Asymmetric Negishi Cross-Couplings of Secondary Allylic Chlorides with Alkylzincs. J. Am. Chem. Soc. 2008;130:2756–2757. This paper describes the use of two sequential nickel-catalyzed asymmetric Negishi cross-coupling reactions in the formal synthesis of fluvirucinine A1. [PubMed]

    52. Suh Y-G, Kim S-A, Jung J-K, Shin D-Y, Min K-H, Koo B-A, Kim H-S. Asymmetric Total Synthesis of Fluvirucinine A1. Angew. Chem., Int. Ed. 1999;38:3545–3547.[PubMed]

    53. Douglas CJ, Overman LE. Catalytic Asymmetric Synthesis of All-Carbon Quaternary Stereocenters. Proc. Natl. Acad. Sci. U.S.A. 2004;101:5363–5367.[PMC free article][PubMed]

    54. Heck RF. Palladium-Catalyzed Reactions of Organic Halides with Olefins. Acc. Chem. Res. 1979;12:146–151.

    55. Overman LE. Application of Intramolecular Heck Reactions for Forming Congested Quaternary Carbon Centers in Complex Molecule Total Synthesis.

    One thought on “R Indacrinone Synthesis Essay

    Leave a comment

    L'indirizzo email non verrà pubblicato. I campi obbligatori sono contrassegnati *